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pentobarbital will reduce the extent or result of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Potent CYP3A4 inducers may well decrease midostaurin concentrations causing minimized efficacy.pentobarbital boosts effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use War